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Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats

Lookup NU author(s): Dr Farhat Jabeen, Dr Abdul ChaudhryORCiD, Dr Muhammad Khan



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© 2017 Springer Science+Business Media, LLC This study assessed the protective effects of Cinnamomum cassia (cinnamon) bark extract in rats exposed to titanium dioxide nanoparticles or titanium dioxide bulk salt. For in vivo evaluation of the ameliorative role of the cinnamon extract, the experimental groups were orally administered with the cinnamon extract at different dose levels (50 or 100 or 150 mg/kg bodyweight) along with the subcutaneous injections of 150 mg/kg bodyweight titanium dioxide nanoparticles or titanium dioxide bulk salt. The extract showed significant ameliorative role on the antioxidant system in response to elevated levels of titanium dioxide nanoparticles or titanium dioxide bulk salt-induced oxidative stress. It aided in the recovery of the antioxidant system as well as protective role in histological damages and some haematological parameters in the rat liver treated with titanium dioxide nanoparticles or titanium dioxide bulk salt.

Publication metadata

Author(s): Shakeel M, Jabeen F, Iqbal R, Chaudhry AS, Zafar S, Ali M, Khan MS, Khalid A, Shabbir S, Asghar MS

Publication type: Article

Publication status: Published

Journal: Biological Trace Element Research

Year: 2018

Volume: 182

Issue: 1

Pages: 57-69

Print publication date: 01/03/2018

Online publication date: 19/06/2017

Acceptance date: 06/06/2017

Date deposited: 22/08/2017

ISSN (print): 0163-4984

ISSN (electronic): 1559-0720

Publisher: Humana Press Inc.


DOI: 10.1007/s12011-017-1074-3


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