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Dietary implications for patients receiving long-term oral anticoagulation therapy for treatment and prevention of thromboembolic disease

Lookup NU author(s): Dr Emma KampourakiORCiD, Professor Farhad Kamali



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2017 Informa UK Limited, trading as Taylor & Francis Group Introduction: The effectiveness of oral anticoagulation therapy with warfarin (a vitamin K antagonist) in the treatment of thromboembolic disease, including stroke prophylaxis in patients with atrial fibrillation is well recognised. However, warfarin has a narrow therapeutic window and an unpredictable anticoagulation response, which make it difficult to achieve and maintain optimal anticoagulation. Various dietary factors, including sudden changes in eating patterns, can significantly alter anticoagulation control, thereby potentially exposing patients to the risk of bleeding or thromboembolic complications. Dietary vitamin K intake is a particularly important factor, given the mechanism of action of warfarin. Areas covered: In this article, we cover the sources of vitamin K and their potential effect of dietary vitamin K on anticoagulation response to warfarin. We also discuss the results of studies on the effect of vitamin K supplementation on anticoagulation stability. Expert commentary: A stable dietary vitamin K, promoted by daily oral vitamin K supplementation, can improve anticoagulation stability in patients on warfarin therapy. There is experimental evidence in animals that dietary vitamin K affects anticoagulation response to the direct thrombin inhibitor, ximelagatran. Whether dietary vitamin K affects anticoagulation response to the currently licensed direct oral anticoagulants (DOACs) in man remains to be investigated.

Publication metadata

Author(s): Kampouraki E, Kamali F

Publication type: Article

Publication status: Published

Journal: Expert Review of Clinical Pharmacology

Year: 2017

Volume: 10

Issue: 8

Pages: 789-797

Online publication date: 21/06/2017

Acceptance date: 20/06/2017

Date deposited: 20/07/2017

ISSN (print): 1751-2433

ISSN (electronic): 1751-2441

Publisher: Taylor and Francis Ltd


DOI: 10.1080/17512433.2017.1345622


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