Lookup NU author(s): Dr Sean O'Dowd,
Dr Brook Galna,
Dr Rosie Morris,
Dr Rachael Lawson,
Dr Claire McDonald,
Dr Alison Yarnall,
Professor David Burn,
Professor Lynn Rochester,
Dr Kirstie Anderson
This is the authors' accepted manuscript of an article that has been published in its final definitive form by IOS Press, 2017.
For re-use rights please refer to the publisher's terms and conditions.
Abnormal sleep may associate with cognitive decline in Parkinson’s disease (PD). Furthermore, sleep dysfunction may associate with worse motor outcome. We hypothesised that PD patients with poor quality sleep would have greater progression in gait dysfunction, due to structural and functional overlap in networks subserving sleep and gait regulation. 12 PD patients and 12 age-matched controls completed longitudinal follow-up over 36 months. Poor sleep efficiency and greater sleep fragmentation correlated significantly with progression of step-width variability, a gait characteristic mediated by postural control, providing evidence that poor sleep in PD is associated with a more rapid deterioration in gait.
Author(s): O'Dowd S, Galna B, Morris R, Lawson RA, McDonald C, Yarnall AJ, Burn DJ, Rochester L, Anderson KN
Publication type: Article
Publication status: Published
Journal: Journal of Parkinson's Disease
Print publication date: 08/08/2017
Online publication date: 30/07/2017
Acceptance date: 11/06/2017
Date deposited: 18/07/2017
ISSN (print): 1877-7171
ISSN (electronic): 1877-718X
Publisher: IOS Press
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