Toggle Main Menu Toggle Search

Open Access padlockePrints

“Smart” Rhythmic Biomaterials for Drug Delivery in Chronopharmacotherapy

Lookup NU author(s): Dr Katarina Novakovic


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


The Holy Grail for optimal drug delivery is delivering only the amount of drug needed, when it is needed, and where it is needed. Optimal drug dosing is particularly challenging when the ideal timing of drug delivery is difficult to achieve in practice e.g. when the ideal dosing time is during sleep and is required repeatedly. A potential solution to this problem are rhythmic biomaterials able to carry and dispense a drug load with a specified rhythm (e.g. once a day at midnight). Recently we have developed a chemical reaction system in which macromolecules can be manipulated to induce periodic changes in concentration of hydrogen ions (i.e. pH). Effort is now directed at the development of oscillatory biocompatible materials that repeatedly expand (swell) and collapse (shrink) at set intervals over long periods of time (days, weeks). This rhythmical oscillation of materials results in the material’s pores opening periodically so that any payload (e.g. drug/s) is rhythmically expelled. Importantly, rhythmic biomaterials are of broader interest being also required for advancing the areas of functional tissue engineering, regenerative medicine, development of artificial muscles and biomimetic robots. In this talk, a route to achieving rhythmic biomaterials will be presented and exciting avenues in healthcare applications will be discussed.

Publication metadata

Author(s): Novakovic K

Editor(s): Mei X

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 7th Annual International Symposium of Drug Delivery Systems

Year of Conference: 2017

Pages: 132

Print publication date: 11/07/2017

Online publication date: 11/07/2017

Acceptance date: 07/03/2017