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Fluoride: Intake and Metabolism, Therapeutic and Toxicological Consequences

Lookup NU author(s): Dr Vida Zohoori, Dr Ralph Duckworth


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© 2017 Elsevier Inc. All rights reserved. Fluoride (F) is present in all soils, water, plants, and animals. The main sources of F intake are diet and the unintentional swallowing of fluoridated dental products. 80-90% of ingested F is absorbed from the gastrointestinal tract by passive diffusion. Almost half of that is excreted in the urine, and the remainder is incorporated in the calcified tissues, which contain 99% of the F in the body. F is the most successful active agent against dental caries. It is also one of the few agents that can stimulate bone cell proliferation and therefore may be of benefit in optimizing bone mineral density, important in maintaining bone health throughout life. Conversely, disturbances of enamel development (dental/enamel fluorosis) and bone homeostasis (skeletal fluorosis) are consequences of excessive retention of F in the body. Several factors can affect F metabolism and consequently F retention, including acid-base disturbance, altitude, physical activity, diet, and genetic predisposition.

Publication metadata

Author(s): Zohoori FV, Duckworth RM

Editor(s): Collins JF

Publication type: Book Chapter

Publication status: Published

Book Title: Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals

Year: 2016

Pages: 539-550

Print publication date: 30/09/2016

Online publication date: 16/09/2016

Acceptance date: 02/04/2016

Publisher: Elsevier Inc.

Place Published: London


DOI: 10.1016/B978-0-12-802168-2.00044-0

Library holdings: Search Newcastle University Library for this item

ISBN: 9780128023761