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Lookup NU author(s): Dr Vida Zohoori, Dr Ralph Duckworth
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© 2017 Elsevier Inc. All rights reserved. Fluoride (F) is present in all soils, water, plants, and animals. The main sources of F intake are diet and the unintentional swallowing of fluoridated dental products. 80-90% of ingested F is absorbed from the gastrointestinal tract by passive diffusion. Almost half of that is excreted in the urine, and the remainder is incorporated in the calcified tissues, which contain 99% of the F in the body. F is the most successful active agent against dental caries. It is also one of the few agents that can stimulate bone cell proliferation and therefore may be of benefit in optimizing bone mineral density, important in maintaining bone health throughout life. Conversely, disturbances of enamel development (dental/enamel fluorosis) and bone homeostasis (skeletal fluorosis) are consequences of excessive retention of F in the body. Several factors can affect F metabolism and consequently F retention, including acid-base disturbance, altitude, physical activity, diet, and genetic predisposition.
Author(s): Zohoori FV, Duckworth RM
Editor(s): Collins JF
Publication type: Book Chapter
Publication status: Published
Book Title: Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals
Year: 2016
Pages: 539-550
Print publication date: 30/09/2016
Online publication date: 16/09/2016
Acceptance date: 02/04/2016
Publisher: Elsevier Inc.
Place Published: London
URL: https://doi.org/10.1016/B978-0-12-802168-2.00044-0
DOI: 10.1016/B978-0-12-802168-2.00044-0
Library holdings: Search Newcastle University Library for this item
ISBN: 9780128023761