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Cell-based tolerogenic therapy, experience from animal models of multiple sclerosis, type 1 diabetes and rheumatoid arthritis

Lookup NU author(s): Professor Catharien Hilkens


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© 2017 Bentham Science Publishers. Cell-based tolerogenic therapy is a promising approach for the treatment of autoimmune diseases and transplant rejection. Regulatory T cells and tolerogenic dendritic cells have been particularly explored in the treatment of various autoimmune disorders in experimental models of disease. Although some of these cells have already been tested in a limited number of clinical trials, there is still a need for preclinical research on tolerogenic cells in animal models of autoimmunity. This review will focus on the relevance of data obtained from studies in experimental animal models for the use of tolerogenic cell-based therapy in humans. Also, perspectives for further improvement of tolerogenic cell preparation towards enhanced suppressive activity and stability of the cells will be discussed.

Publication metadata

Author(s): Stojanovic I, Dimitrijevic M, Vives-Pi M, Mansilla MJ, Pujol-Autonell I, Rodriguez-Fernandez S, Palova-Jelinkova L, Funda DP, Gruden-Movsesijan A, Sofronic-Milosavljevic L, Hilkens CMU, Martinez Caceres E, Miljkovic D

Publication type: Review

Publication status: Published

Journal: Current Pharmaceutical Design

Year: 2017

Volume: 23

Issue: 18

Pages: 2623-2643

Online publication date: 01/05/2017

Acceptance date: 02/04/2016

ISSN (print): 1381-6128

ISSN (electronic): 1873-4286

Publisher: Bentham Science Publishers B.V.


DOI: 10.2174/1381612823666170214120708