Short-term Storage of Cells for Application in Cell-based Therapies

Swioklo, S; Connon, CJ

doi:10.1002/9781118743362.ch7

Short-term Storage of Cells for Application in Cell-based Therapies

Lookup NU author(s): Dr Stephen Swioklo, Professor Che Connon ORCiD

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Abstract

© 2017 by John Wiley & Sons, Ltd. All rights reserved. The clinical application of cell-based therapeutics is ever-accelerating with the number of novel clinical trials demonstrating a dramatic increase in the last decade, accompanied by an emergence of approved cell therapy products (CTPs) to the market. One of the major bottlenecks for CTPs, however, is in the short-term storage of cells for quality, safety and efficacy testing, and their distribution from the donor or bank, to sites of processing, and back to the clinic. This chapter examines the potential for hypothermic cell preservation as a solution to overcome many of these challenges associated with the cell therapy supply chain. With special attention paid to therapeutically relevant mesenchymal stem cells (MSCs), current progress in hypothermic cell preservation is highlighted, exploring the optimal storage conditions for viable cell recovery and function. The potential benefits for implementation at different stages of the cell therapy supply chain are outlined, and the future challenges associated with developing a robust, scalable platform for extended cell preservation are discussed.