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Systemic Inflammation in Lewy Body Diseases: A Systematic Review

Lookup NU author(s): Dr Eleanor King, Professor Alan ThomasORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Objectives Few studies have investigated the role of inflammation in Lewy Body Dementia (LBD) and variable results have been found. We systematically reviewed the literature for evidence of systemic inflammatory changes in Dementia with Lewy Bodies (DLB) and Parkinson’s Disease Dementia (PDD). Due to the low number of studies we also included Parkinson’s disease (PD). Methods Key terms were used to search the relevant databases. Titles and abstracts were screened and potentially relevant articles were reviewed in full. References of included studies and relevant reviews were searched. Results The database search returned 2166 results, 46 of which were finally included in the systematic review. These studies showed a general increase in inflammatory markers in the peripheral blood, most notably interleukin-1beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-10. Studies examining cerebrospinal fluid (CSF) found interleukin-1beta, interleukin-6 and transforming growth factor-beta1 to be particularly increased, and interferon-gamma decreased. C-reactive protein levels were increased, particularly in PDD. Conclusions These results provide evidence that LBD is associated with an increased inflammatory response. Furthermore, there may be a stronger general inflammatory response in LBD than in PD, whilst complex changes occur in the individual cytokines.

Publication metadata

Author(s): King E, Thomas A

Publication type: Article

Publication status: Published

Journal: Alzheimer Disease and Associated Disorders

Year: 2017

Volume: 31

Issue: 4

Pages: 346-356

Print publication date: 01/10/2017

Online publication date: 09/10/2017

Acceptance date: 18/07/2017

Date deposited: 15/08/2017

ISSN (print): 0893-0341

ISSN (electronic): 1546-4156

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/WAD.0000000000000211


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