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Lookup NU author(s): Dr Eleanor King, Professor Alan ThomasORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Objectives Few studies have investigated the role of inflammation in Lewy Body Dementia (LBD) and variable results have been found. We systematically reviewed the literature for evidence of systemic inflammatory changes in Dementia with Lewy Bodies (DLB) and Parkinson’s Disease Dementia (PDD). Due to the low number of studies we also included Parkinson’s disease (PD). Methods Key terms were used to search the relevant databases. Titles and abstracts were screened and potentially relevant articles were reviewed in full. References of included studies and relevant reviews were searched. Results The database search returned 2166 results, 46 of which were finally included in the systematic review. These studies showed a general increase in inflammatory markers in the peripheral blood, most notably interleukin-1beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-10. Studies examining cerebrospinal fluid (CSF) found interleukin-1beta, interleukin-6 and transforming growth factor-beta1 to be particularly increased, and interferon-gamma decreased. C-reactive protein levels were increased, particularly in PDD. Conclusions These results provide evidence that LBD is associated with an increased inflammatory response. Furthermore, there may be a stronger general inflammatory response in LBD than in PD, whilst complex changes occur in the individual cytokines.
Author(s): King E, Thomas A
Publication type: Article
Publication status: Published
Journal: Alzheimer Disease and Associated Disorders
Year: 2017
Volume: 31
Issue: 4
Pages: 346-356
Print publication date: 01/10/2017
Online publication date: 09/10/2017
Acceptance date: 18/07/2017
Date deposited: 15/08/2017
ISSN (print): 0893-0341
ISSN (electronic): 1546-4156
Publisher: Lippincott Williams & Wilkins
URL: https://doi.org/10.1097/WAD.0000000000000211
DOI: 10.1097/WAD.0000000000000211
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