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Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-β levels in APP/PS1 transgenic mice

Lookup NU author(s): Professor Moein MoghimiORCiD


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© 2015 Elsevier Inc. The accumulation of extracellular amyloid-beta (Aβ) peptide and intracellular neurofibrillary tangles in the brain are two major neuropathological hallmarks of Alzheimer's disease (AD). It is thought that an equilibrium exists between Aβ in the brain and in the peripheral blood and thus, it was hypothesized that shifting this equilibrium towards the blood by enhancing peripheral clearance might reduce Aβ levels in the brain: the 'sink effect'. We tested this hypothesis by intraperitoneally injecting APP/PS1 transgenic mice with small unilamellar vesicles containing either phosphatidic acid or cardiolipin over 3. weeks. This treatment reduced significantly the amount of Aβ in the plasma and the brain levels of Aβ were lighter affected. Nevertheless, this dosing regimen did modulate tau phosphorylation and glycogen synthase kinase 3 activities in the brain, suggesting that the targeting of circulating Aβ may be therapeutically relevant in AD.

Publication metadata

Author(s): Ordonez-Gutierrez L, Re F, Bereczki E, Ioja E, Gregori M, Andersen AJ, Anton M, Moghimi SM, Pei J-J, Masserini M, Wandosell F

Publication type: Article

Publication status: Published

Journal: Nanomedicine: Nanotechnology, Biology and Medicine

Year: 2015

Volume: 11

Issue: 2

Pages: 421-430

Print publication date: 01/02/2015

Online publication date: 14/11/2014

Acceptance date: 28/09/2014

ISSN (print): 1549-9634

ISSN (electronic): 1549-9642

Publisher: Elsevier Inc.


DOI: 10.1016/j.nano.2014.09.015

PubMed id: 25461285


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