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Change in model for end-stage liver disease score on the transplant waiting list predicts survival in patients undergoing liver transplantation

Lookup NU author(s): Dr Stuart Kendrick


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Allocation of donor livers through the model for end-stage liver disease (MELD) score has resulted in a fall in waiting list deaths in the United States. Change in MELD score (DeltaMELD) whilst awaiting transplant has been suggested as a method of refining organ allocation. Our aims were to analyse the effect of DeltaMELD between listing and transplant, and examine its impact on patient survival, intensive care stay and hospital stay in 402 patients transplanted for chronic liver disease at a single centre. Patients who had a DeltaMELD score of >+1 point were more likely to die in hospital following transplant (P < 0.05) and had a significantly worse 12- and 36-month survival post transplant (P < 0.0001) when compared with patients with DeltaMELD < 0.001). In conclusion, change in MELD score whilst on the transplant waiting list has a significant effect on survival post-transplant although MELD score at the time of transplant appears to have the most significant effect on resource utilization.

Publication metadata

Author(s): Foxton MR, Kendrick S, Sizer E, Muiesan P, Rela M, Wendon J, Heaton ND, O'Grady JG, Heneghan MA

Publication type: Article

Publication status: Published

Journal: Transplant International

Year: 2006

Volume: 19

Issue: 12

Pages: 988-994

ISSN (print): 0934-0874

ISSN (electronic): 1432-2277

Publisher: Wiley-Blackwell


DOI: 10.1111/j.1432-2277.2006.00377.x

Notes: Journal Article Germany official journal of the European Society for Organ Transplantation


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