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Epilepsy and bipolar disorder

Lookup NU author(s): Dr Rhys ThomasORCiD


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© 2015 Elsevier Inc. It is well recognized that mood disorders and epilepsy commonly co-occur. Despite this, our knowledge regarding the relationship between epilepsy and bipolar disorder is limited. Several shared features between the two disorders, such as their episodic nature and potential to run a chronic course, and the efficacy of some antiepileptic medications in the prophylaxis of both disorders, are often cited as evidence of possible shared underlying pathophysiology. The present paper aims to review the bidirectional associations between epilepsy and bipolar disorder, with a focus on epidemiological links, evidence for shared etiology, and the impact of these disorders on both the individual and wider society. Better recognition and understanding of these two complex disorders, along with an integrated clinical approach, are crucial for improved evaluation and management of comorbid epilepsy and mood disorders.

Publication metadata

Author(s): Knott S, Forty L, Craddock N, Thomas RH

Publication type: Review

Publication status: Published

Journal: Epilepsy and Behavior

Year: 2015

Volume: 52

Issue: Part A

Pages: 267-274

Print publication date: 01/11/2015

Online publication date: 25/08/2015

Acceptance date: 02/07/2015

ISSN (print): 1525-5050

ISSN (electronic): 1525-5069

Publisher: Academic Press Inc.


DOI: 10.1016/j.yebeh.2015.07.003

PubMed id: 26316422