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Cluster of atypical adult Guillain-Barré syndrome temporally associated with neurological illness due to EV-D68 in children, South Wales, United Kingdom, October 2015 to January 2016

Lookup NU author(s): Dr Rhys ThomasORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2016, European Centre for Disease Prevention and Control (ECDC). All rights reserved.We report a cluster of atypical Guillain-Barré syn-drome in 10 adults temporally related to a cluster of four children with acute flaccid paralysis, over a 3-month period in South Wales, United Kingdom. All adult cases were male, aged between 24 and 77 years. Seven had prominent facial diplegia at onset. Available electrophysiological studies showed axonal involvement in five adults. Seven reported various forms of respiratory disease before onset of neuro-logical symptoms. The ages of children ranged from one to 13 years, three of the four were two years old or younger. Enterovirus testing is available for three chil-dren; two had evidence of enterovirus D68 infection in stool or respiratory samples. We describe the clinical features, epidemiology and state of current investiga-tions for these unusual clusters of illness.

Publication metadata

Author(s): Williams CJ, Thomas RH, Pickersgill TP, Lyons M, Lowe G, Stiff RE, Moore C, Jones R, Howe R, Brunt H, Ashman A, Mason BW

Publication type: Article

Publication status: Published

Journal: Eurosurveillance

Year: 2016

Volume: 21

Issue: 4

Pages: 26-32

Online publication date: 28/01/2016

Acceptance date: 28/01/2016

Date deposited: 07/09/2017

ISSN (print): 1025-496X

ISSN (electronic): 1560-7917

Publisher: European Centre for Disease Prevention and Control (ECDC)


DOI: 10.2807/1560-7917.ES.2016.21.4.30119


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