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Stabilisation of an amorphous form of ROY through a predicted co-former interaction

Lookup NU author(s): Dr Jonathan Harburn



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


The highly polymorphic compound ROY, notorious for the colour of its crystals, was the subject of an optimised high-throughput ultrasound-based co-crystal screen. This screen involved a computational pre-screen which highlighted an interaction between ROY and the potential co-former pyrogallol. We have shown that the presence of pyrogallol stabilises the amorphous form of ROY, highlighting the potential for future prediction of co-amorphous behaviours.

Publication metadata

Author(s): Corner PA, Harburn JJ, Steed JW, McCabe JF, Berry DJ

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2016

Volume: 52

Issue: 39

Pages: 6537-6540

Print publication date: 14/05/2016

Online publication date: 18/04/2016

Acceptance date: 18/04/2016

Date deposited: 26/09/2017

ISSN (print): 1359-7345

ISSN (electronic): 0009-241X

Publisher: Royal Society of Chemistry


DOI: 10.1039/C6CC02949C


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