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Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking

Lookup NU author(s): Professor Moein MoghimiORCiD

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Abstract

A simple and highly safe poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticulate delivery system that targets different cell types is developed. A sub-cytotoxic level of polyethylenimine coat mediates universal cell targeting. Internalized nanoparticles traffic along endolysosomal compartments, endoplasmic reticulum and the Golgi complex. Nanoparticles have no detrimental effects on cell morphology and respiration. © 2014 WILEY-VCH Verlag GmbH & Co.

Publication metadata

Author(s): Wu L-P, Wang D, Parhamifar L, Hall A, Chen G-Q, Moghimi SM

Publication type: Article

Publication status: Published

Journal: Advanced Healthcare Materials

Year: 2014

Volume: 3

Issue: 6

Pages: 817-824

Print publication date: 01/06/2014

Online publication date: 10/01/2014

Acceptance date: 14/11/2013

ISSN (print): 2192-2640

ISSN (electronic): 2192-2659

Publisher: Wiley-VCH Verlag

URL: https://doi.org/10.1002/adhm.201300533

DOI: 10.1002/adhm.201300533

PubMed id: 24408356

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