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Lookup NU author(s): Professor Moein MoghimiORCiD
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© 2015 American Chemical Society.Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.
Author(s): Wu L-P, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM
Publication type: Review
Publication status: Published
Journal: Bioconjugate Chemistry
Online publication date: 05/02/2015
Acceptance date: 01/01/1900
ISSN (print): 1043-1802
ISSN (electronic): 1520-4812
Publisher: American Chemical Society
PubMed id: 25654320