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Insidious pathogen-mimicking properties of nanoparticles in triggering the lectin pathway of the complement system

Lookup NU author(s): Professor Moein MoghimiORCiD, Dr Linping Wu

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Abstract

© 2015 by De Gruyter 2015.The lectin pathway of the complement system is an integral component of the innate immune system recognizing pathogens through patterns of sugar moieties displayed on their surfaces and neutralizing them through an antibody-independent reaction cascade. Many engineered nanoparticles incite complement through the lectin pathway, but these nanoparticles inherently do not express surface-exposed sugars. However, the projected polymeric surface architecture of nanoparticles may transiently resemble structural motifs of peptidoglycan constituents of pathogens and trigger the lectin pathway. We discuss these issues in relation to nanomedicine design and immune safety.

Publication metadata

Author(s): Moghimi SM, Wibroe PP, Wu L, Farhangrazi ZS

Publication type: Review

Publication status: Published

Journal: European Journal of Nanomedicine

Year: 2015

Volume: 7

Issue: 3

Pages: 263-268

Print publication date: 01/06/2015

Online publication date: 29/04/2015

Acceptance date: 01/01/1900

ISSN (print): 1662-5986

ISSN (electronic): 1662-596X

Publisher: Walter de Gruyter GmbH

URL: https://doi.org/10.1515/ejnm-2015-0014

DOI: 10.1515/ejnm-2015-0014

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