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Lookup NU author(s): Dr Linping Wu,
Professor Moein MoghimiORCiD
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© 2015 American Chemical Society. The inverted-type liquid-crystalline dispersions comprising cubosomes and hexosomes hold much potential for drug solubilization and site-specific targeting on intravenous administration. Limited information, however, is available on the influence of plasma components on nanostructural and morphological features of cubosome and hexosome dispersions, which may modulate their stability in the blood and their overall biological performance. Through an integrated approach involving SAXS, cryo-TEM, and nanoparticle tracking analysis (NTA) we have studied the time-dependent effect of human plasma (and the plasma complement system) on the integrity of the internal nanostructure, morphology, and fluctuation in size distribution of phytantriol (PHYT)-based nonlamellar crystalline dispersions. The results indicate that in the presence of plasma the internal nanostructure undergoes a transition from the biphasic phase (a bicontinuous cubic phase with symmetry Pn3m coexisting with an inverted-type hexagonal (H2) phase) to a neat hexagonal (H2) phase, which decreases the median particle size. These observations were independent of a direct effect by serum albumin and dispersion-mediated complement activation. The implication of these observations in relation to soft nanocarrier design for intravenous drug delivery is discussed.
Author(s): Mat Azmi ID, Wu L, Wibroe PP, Nilsson C, Ostergaard J, Sturup S, Gammelgaard B, Urtti A, Moghimi SM, Yaghmur A
Publication type: Article
Publication status: Published
Print publication date: 12/05/2015
Online publication date: 17/04/2015
Acceptance date: 07/04/2015
ISSN (print): 0743-7463
ISSN (electronic): 1520-5827
Publisher: American Chemical Society
PubMed id: 25884233
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