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Modulatory Effect of Human Plasma on the Internal Nanostructure and Size Characteristics of Liquid-Crystalline Nanocarriers

Lookup NU author(s): Dr Linping Wu, Professor Moein MoghimiORCiD


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© 2015 American Chemical Society. The inverted-type liquid-crystalline dispersions comprising cubosomes and hexosomes hold much potential for drug solubilization and site-specific targeting on intravenous administration. Limited information, however, is available on the influence of plasma components on nanostructural and morphological features of cubosome and hexosome dispersions, which may modulate their stability in the blood and their overall biological performance. Through an integrated approach involving SAXS, cryo-TEM, and nanoparticle tracking analysis (NTA) we have studied the time-dependent effect of human plasma (and the plasma complement system) on the integrity of the internal nanostructure, morphology, and fluctuation in size distribution of phytantriol (PHYT)-based nonlamellar crystalline dispersions. The results indicate that in the presence of plasma the internal nanostructure undergoes a transition from the biphasic phase (a bicontinuous cubic phase with symmetry Pn3m coexisting with an inverted-type hexagonal (H2) phase) to a neat hexagonal (H2) phase, which decreases the median particle size. These observations were independent of a direct effect by serum albumin and dispersion-mediated complement activation. The implication of these observations in relation to soft nanocarrier design for intravenous drug delivery is discussed.

Publication metadata

Author(s): Mat Azmi ID, Wu L, Wibroe PP, Nilsson C, Ostergaard J, Sturup S, Gammelgaard B, Urtti A, Moghimi SM, Yaghmur A

Publication type: Article

Publication status: Published

Journal: Langmuir

Year: 2015

Volume: 31

Issue: 18

Pages: 5042-5049

Print publication date: 12/05/2015

Online publication date: 17/04/2015

Acceptance date: 07/04/2015

ISSN (print): 0743-7463

ISSN (electronic): 1520-5827

Publisher: American Chemical Society


DOI: 10.1021/acs.langmuir.5b00830

PubMed id: 25884233


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