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Lookup NU author(s): Dr Glyn NelsonORCiD, Dr Olena Kucheryavenko, James Wordsworth, Professor Thomas von Zglinicki
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2017 The Authors. Cell senescence is an important driver of the ageing process. The accumulation of senescent cells in tissues is accelerated by stress signals from senescent cells that induce DNA damage and ultimately senescence in bystander cells. We examine here the interplay of senescence-associated mitochondrial dysfunction (SAMD)-driven production of reactive oxygen species (ROS) and senescence-associated secretory phenotype (SASP) in causing the bystander effect. We show that in various modes of fibroblast senescence ROS are necessary and sufficient to activate the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which facilitates a large part of the SASP. This ROS-NF-κB axis causes the DNA damage response in bystander cells. Cytokines IL-6 and IL-8 are major components of the pro-inflammatory SASP in senescent fibroblasts. However, their activation in senescence is only partially controlled by NF-κB, and they are thus not strong candidates as intercellular mediators of the bystander effect as mediated by the ROS-NF-κB axis.
Author(s): Nelson G, Kucheryavenko O, Wordsworth J, von Zglinicki T
Publication type: Article
Publication status: Published
Journal: Mechanisms of Ageing and Development
Year: 2018
Volume: 170
Pages: 30-36
Print publication date: 01/03/2018
Online publication date: 25/08/2017
Acceptance date: 14/08/2017
Date deposited: 29/09/2017
ISSN (print): 0047-6374
ISSN (electronic): 1872-6216
Publisher: Elsevier
URL: https://doi.org/10.1016/j.mad.2017.08.005
DOI: 10.1016/j.mad.2017.08.005
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