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Lookup NU author(s): Professor Nicola Curtin
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© 2017, Springer Science+Business Media LLC. This chapter describes some of the techniques in use in our laboratories for the investigation of PARP inhibitors in clinical medicine. More specifically, we are involved in investigating the utility of PARP inhibitors in the treatment of hematopoietic malignancies. We are also actively investigating the properties of the PARP systems in cell biology. We begin the chapter with a very brief history of the invention and use of PARP inhibitors. We then explain the underlying logic of the use of PARP inhibitors either in combination with chemo- or radiotherapy or as single agents used alone. We then provide in full detail the protocols that we use to study PARP inhibitors in cell biology to identify patients that should be susceptible to PARP inhibitor treatment and to manage and investigate these patients throughout their treatment.
Author(s): Shall S, Gaymes T, Farzaneh F, Curtin NJ, Mufti GJ
Publication type: Book Chapter
Publication status: Published
Book Title: Methods in Molecular Biology
Online publication date: 11/07/2017
Acceptance date: 20/04/2016
Publisher: Humana Press Inc.
Place Published: New York
Library holdings: Search Newcastle University Library for this item