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The use of PARP inhibitors in cancer therapy: Use as adjuvant with chemotherapy or radiotherapy, use as a single agent in susceptible patients, and techniques used to identify susceptible patients

Lookup NU author(s): Professor Nicola CurtinORCiD


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© 2017, Springer Science+Business Media LLC. This chapter describes some of the techniques in use in our laboratories for the investigation of PARP inhibitors in clinical medicine. More specifically, we are involved in investigating the utility of PARP inhibitors in the treatment of hematopoietic malignancies. We are also actively investigating the properties of the PARP systems in cell biology. We begin the chapter with a very brief history of the invention and use of PARP inhibitors. We then explain the underlying logic of the use of PARP inhibitors either in combination with chemo- or radiotherapy or as single agents used alone. We then provide in full detail the protocols that we use to study PARP inhibitors in cell biology to identify patients that should be susceptible to PARP inhibitor treatment and to manage and investigate these patients throughout their treatment.

Publication metadata

Author(s): Shall S, Gaymes T, Farzaneh F, Curtin NJ, Mufti GJ

Publication type: Book Chapter

Publication status: Published

Book Title: Methods in Molecular Biology

Year: 2017

Volume: 1608

Pages: 343-370

Online publication date: 11/07/2017

Acceptance date: 20/04/2016

Publisher: Humana Press Inc.

Place Published: New York


DOI: 10.1007/978-1-4939-6993-7_23

Library holdings: Search Newcastle University Library for this item

ISBN: 9781493969937