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Comparative Anesthesia and Analgesia of Laboratory Animals

Lookup NU author(s): Emeritus Professor Paul FlecknellORCiD, Dr Aurelie Thomas


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© 2015 by John Wiley & Sons, Inc. This chapter describes some properties of commonly used sedative, anesthetic, and analgesic agents for laboratory animals. Inhalants (mainly isoflurane and sevoflurane) are becoming increasingly popular in laboratory animal anesthesia for a number of reasons. Chloral hydrate is used occasionally in rodent anesthesia for neuropharmacology studies. Tribromoethanol is used primarily in mice although its popularity has declined markedly because of undesirable side-effects. Despite growing emphasis on animal welfare and refinement of animal models, less than 25% of laboratory rodents undergoing surgical procedure are given analgesic drugs. Non-steroidal anti-inflammatory drugs (NSAIDs) are the second most commonly administered agents for pain relief in rodents and other laboratory animal species. Despite their abundant use in animal models of chronic pain, very few studies have looked at the benefit of gabapentin and pregabalin in laboratory animals as part of postsurgical pain management. Finally, the chapter discusses laboratory rodents and lagomorphs, and non-human primates.

Publication metadata

Author(s): Flecknell PA, Thomas AA

Publication type: Book Chapter

Publication status: Published

Book Title: Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones

Year: 2017

Pages: 754-763

Online publication date: 28/04/2017

Acceptance date: 02/04/2016

Publisher: Wiley


DOI: 10.1002/9781119421375.ch39

Library holdings: Search Newcastle University Library for this item

ISBN: 9781119421375