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Results of a multicentre UK-wide retrospective study evaluating the efficacy of brentuximab vedotin in relapsed, refractory classical Hodgkin lymphoma in the transplant naive setting

Lookup NU author(s): Dr Wendy Osborne

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Abstract

© 2017 John Wiley & Sons Ltd. Relapsed or refractory classical Hodgkin lymphoma (cHL) is associated with a poor outcome when standard chemotherapy fails. Brentuximab vedotin (BV) is an anti-CD30 monoclonal antibody-drug conjugate licensed for use at relapse after autologous stem cell transplant (ASCT) or following two prior therapies in those unsuitable for ASCT. There are limited data assessing the ability of BV to enable curative SCT. We performed a UK-wide retrospective study of 99 SCT-naïve relapsed/refractory cHL. All had received 2 prior lines and were deemed fit for transplant but had an insufficient remission to proceed. The median age was 32 years. Most had nodular sclerosis subtype, Eastern Cooperative Oncology Group performance status 0-1 and advanced stage disease. The median progression-free survival (PFS) was 5·6 months and median overall survival (OS) was 37·2 months. The overall response rate was 56% (29% complete response; 27% partial response). 61% reached SCT: 34% immediately post-BV and 27% following an inadequate BV response but were salvaged and underwent deferred SCT. Patients consolidated with SCT had a superior PFS and OS to those not receiving SCT (P < 0·001). BV is an effective, non-toxic bridge to immediate SCT in 34% and deferred SCT in 27%. 39% never reached SCT with a PFS of 3·0 months, demonstrating the unmet need to improve outcomes in those unsuitable for SCT post-BV.

Publication metadata

Author(s): Eyre TA, Phillips EH, Linton KM, Kassam S, Gibb A, Allibone S, Radford J, Peggs K, Burton C, Stewart G, Ledieu R, Booth C, Osborne WL, Miall F, Eyre DW, Ardeshna KM, Collins GP

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2017

Volume: 179

Issue: 3

Pages: 471-479

Print publication date: 01/11/2017

Online publication date: 31/08/2017

Acceptance date: 18/07/2017

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: John Wiley & Sons Ltd

URL: https://doi.org/10.1111/bjh.14898

DOI: 10.1111/bjh.14898

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