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Extra-axial cerebrospinal fluid spaces in children with benign external hydrocephalus: A case-control study

Lookup NU author(s): Patrick Mitchell


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© 2017 SAGE Publications. Background The distinction between normal and pathological extra-axial cerebrospinal fluid (CSF) spaces is unclear, with the use of the term benign external hydrocephalus (BEH) not being well defined in clinical practice. This study aimed to establish a distribution of metrics of the subarachnoid space in a population of children diagnosed as normal, and investigate the clinical use of the term BEH. Methods A retrospective case-control study on magnetic resonance image scans was performed on 150 children diagnosed as normal and 10 children diagnosed with BEH. Measurements were taken in the axial plane for CSF width (CSFW), and interhemispheric width (IHW). Results Normal controls had a mean age of 11.1 ± 7.6 months (78 male, 72 female) and the BEH sample had a mean age of 10.6 ± 7.8 months (six male, four female). Mean CSFW was 7.96 ± 4.79 mm in the BEH sample compared to 4.58 ± 2.25 mm in the normal sample (p < 0.05). Mean IHW was 6.30 ± 2.79 mm in the BEH sample compared to 3.89 ± 1.83 mm in the normal sample (p < 0.05). However, a substantial overlap between the two distributions of CSFW was found, with 50% of BEH patients lying within a single standard deviation of the mean of normal individuals. Conclusion The absence of diagnostic criteria for BEH means reporting is variable. Patients being diagnosed with BEH who have no other clinical defects may represent the extreme of the normal population rather than a distinct clinical entity.

Publication metadata

Author(s): Hussain ZB, Hussain AB, Mitchell P

Publication type: Article

Publication status: Published

Journal: Neuroradiology Journal

Year: 2017

Volume: 30

Issue: 5

Pages: 410-417

Print publication date: 01/10/2017

Online publication date: 10/07/2017

Acceptance date: 02/04/2016

ISSN (print): 1971-4009

ISSN (electronic): 2385-1996

Publisher: SAGE Publications Inc.


DOI: 10.1177/1971400917719298


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