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Skin Deep: The Basics of Human Skin Structure and Drug Penetration

Lookup NU author(s): Dr Keng Wooi NgORCiD, Dr Wing Man LauORCiD


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Drug penetration and permeation through the skin are greatly influenced by the structural properties of the skin and the physicochemical properties of the drug. As such, penetration enhancement techniques largely focus on manipulating these two key factors. A great deal of research has focused on the stratum corneum, the primary skin barrier. In this chapter, we describe the structural properties of human skin, its functions, and the basic principles of drug penetration. The lipid composition and structural organisation of the stratum corneum, as well as the pathways of drug permeation, are highlighted. This chapter should provide a basic understanding of these topics and prepare the reader for advanced discussions in the specialist chapters that follow.

Publication metadata

Author(s): Ng KW, Lau WM

Editor(s): Dragicevic, N; Maibach, H

Publication type: Book Chapter

Publication status: Published

Book Title: Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Year: 2015

Pages: 3-11

Print publication date: 17/10/2016

Acceptance date: 01/01/2014

Publisher: Springer

Place Published: Berlin, Heidelberg


DOI: 10.1007/978-3-662-45013-0_1

Library holdings: Search Newcastle University Library for this item

ISBN: 9783662450123