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Synergy between chemical penetration enhancers

Lookup NU author(s): Dr Keng Wooi NgORCiD, Dr Wing Man LauORCiD


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Synergistic combinations of chemical penetration enhancers are important considerations in drug formulation because they can greatly influence transdermal drug delivery, positively or negatively. This chapter describes how synergistic actions between chemical penetration enhancers can be defined, discovered and measured. The chapter considers literature reports where both positive and negative synergism between chemical penetration enhancers have been described. The underlying mechanisms of action that result in enhancer synergy are also discussed.

Publication metadata

Author(s): Ng KW, Lau WM, Williams AC

Editor(s): Dragicevic, N; Maibach, H

Publication type: Book Chapter

Publication status: Published

Book Title: Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Year: 2015

Pages: 373-385

Print publication date: 01/01/2015

Acceptance date: 01/01/2014

Publisher: Springer

Place Published: Berlin, Heidelberg


DOI: 10.1007/978-3-662-47039-8_24

Library holdings: Search Newcastle University Library for this item

ISBN: 9783662470381