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Finite and infinite dosing

Lookup NU author(s): Dr Wing Man LauORCiD, Dr Keng Wooi NgORCiD


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Due to the popularity of topical and transdermal drug delivery, there is a high demand for reliable skin penetration and permeation data. Compared to in vivo methods, in vitro methods enable these data to be more easily obtained in a shorter time. Two dosing regimens are commonly used to model transdermal drug delivery in vitro, namely, finite dosing and infinite dosing. These dosing regimens are useful in different situations and allow different absorption parameters to be determined empirically. The choice between these regimens depends upon the applicability of the underlying assumptions in a given in-use situation. This chapter provides an overview on finite and infinite dose regimens used in transdermal delivery research, and discuss the advantages and limitations of such regimens.

Publication metadata

Author(s): Lau WM, Ng KW

Editor(s): Dragicevic, N; Maibach, HI

Publication type: Book Chapter

Publication status: Published

Book Title: Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin

Year: 2017

Pages: 35-44

Print publication date: 12/05/2017

Online publication date: 05/05/2017

Acceptance date: 01/01/2014

Publisher: Springer

Place Published: Berlin, Heidelberg


DOI: 10.1007/978-3-662-53270-6_3

Library holdings: Search Newcastle University Library for this item

ISBN: 9783662532683