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Lookup NU author(s): Dr Wing Man Lau,
Dr Keng Wooi Ng
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Due to the popularity of topical and transdermal drug delivery, there is a high demand for reliable skin penetration and permeation data. Compared to in vivo methods, in vitro methods enable these data to be more easily obtained in a shorter time. Two dosing regimens are commonly used to model transdermal drug delivery in vitro, namely, finite dosing and infinite dosing. These dosing regimens are useful in different situations and allow different absorption parameters to be determined empirically. The choice between these regimens depends upon the applicability of the underlying assumptions in a given in-use situation. This chapter provides an overview on finite and infinite dose regimens used in transdermal delivery research, and discuss the advantages and limitations of such regimens.
Author(s): Lau WM, Ng KW
Editor(s): Dragicevic, N; Maibach, HI
Publication type: Book Chapter
Publication status: Published
Book Title: Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin
Print publication date: 12/05/2017
Online publication date: 05/05/2017
Acceptance date: 01/01/2014
Place Published: Berlin, Heidelberg
Library holdings: Search Newcastle University Library for this item