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Lookup NU author(s): Dr Rachel Spiering,
Professor John IsaacsORCiD,
Professor Catharien Hilkens
This is the authors' accepted manuscript of a review that has been published in its final definitive form by Blackwell Publishing Ltd, 2018.
For re-use rights please refer to the publisher's terms and conditions.
© 2017 John Wiley & Sons Ltd. Tolerogenic dendritic cells (tolDCs) are a promising therapeutic tool to restore immune tolerance in autoimmune diseases. The rationale of using tolDCs is that they can specifically target the pathogenic T-cell response while leaving other, protective, T-cell responses intact. Several ways of generating therapeutic tolDCs have been described, but whether these tolDCs should be loaded with autoantigen(s), and if so, with which autoantigen(s), remains unclear. Autoimmune diseases, such as rheumatoid arthritis, are not commonly defined by a single, universal, autoantigen. A possible solution is to use surrogate autoantigens for loading of tolDCs. We propose that heat-shock proteins may be a relevant surrogate antigen, as they are evolutionarily conserved between species, ubiquitously expressed in inflamed tissues and have been shown to induce regulatory T cells, ameliorating disease in various arthritis mouse models. In this review, we provide an overview on how immune tolerance may be restored by tolDCs, the problem of selecting relevant autoantigens for loading of tolDCs, and why heat-shock proteins could be used as surrogate autoantigens.
Author(s): Jansen MAA, Spiering R, Broere F, van Laar JM, Isaacs JD, van Eden W, Hilkens CMU
Publication type: Review
Publication status: Published
Print publication date: 01/01/2018
Online publication date: 18/09/2017
Acceptance date: 04/08/2017
ISSN (print): 0019-2805
ISSN (electronic): 1365-2567
Publisher: Blackwell Publishing Ltd