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Advances in intravesical drug delivery systems to treat bladder cancer

Lookup NU author(s): Dr Wing Man LauORCiD

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Abstract

Chemotherapeutic agents administered intravesically to treat bladder cancer have limited efficacy due to periodic dilution and wash-out during urine formation and elimination. This review describes the pathophysiology, prevalence and staging of bladder cancer, and discusses several formulation strategies used to improve drug residence within the bladder. These include the use of amphiphilic copolymers, mucoadhesive formulations, hydrogels, floating systems, and liposomes. Various in vitro and in vivo models recently employed for intravesical drug delivery studies are discussed. Some of the challenges that have prevented the clinical use of some promising formulations are identified.

Publication metadata

Author(s): Kolawole OM, Lau WM, Mostafid H, Khutoryanskiy VV

Publication type: Review

Publication status: Published

Journal: International Journal of Pharmaceutics

Year: 2017

Volume: 532

Issue: 1

Pages: 105-117

Print publication date: 30/10/2017

Online publication date: 01/09/2017

Acceptance date: 24/08/2017

ISSN (print): 0378-5173

ISSN (electronic): 1873-3476

Publisher: Elsevier

URL: https://doi.org/10.1016/j.ijpharm.2017.08.120

DOI: 10.1016/j.ijpharm.2017.08.120

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