Browse by author
Lookup NU author(s): Dr Wing Man LauORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
PurposeThis work probed the topical delivery and skin-staining properties of a novel co-drug, naproxyl-dithranol (Nap-DTH), which comprises anti-inflammatory (naproxen) and anti-proliferative (dithranol) moieties.MethodFreshly excised, full-thickness porcine ear skin was dosed with saturated solutions of the compounds. After 24 h, the skin was recovered and used to prepare comparative depth profiles by the tape-stripping technique and to examine the extent of skin staining.ResultsDepth profiles showed that Nap-DTH led to a 5-fold increase in drug retention in the skin compared to dithranol. The application of Nap-DTH also demonstrated improved stability, resulting in lower levels of dithranol degradation products in the skin. Furthermore, significantly less naproxen from hydrolysed Nap-DTH permeated into the receptor phase compared to naproxen when applied alone (0.08 ± 0.03 nmol cm-² and 180 ± 60 nmol cm-², respectively). Moreover, the reduced staining of the skin was very apparent for Nap-DTH compared to dithranol.ConclusionsTopical delivery of Nap-DTH not only improves the delivery of naproxen and dithranol, but also reduces unwanted effects of the parent moieties, in particular the skin staining, which is a major issue concerning the use of dithranol.
Author(s): Lau WM, White AW, Heard CH
Publication type: Article
Publication status: Published
Journal: Pharmaceutical Research
Print publication date: 01/12/2010
Online publication date: 25/09/2010
ISSN (print): 0724-8741
ISSN (electronic): 1573-904X
Altmetrics provided by Altmetric