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Reproductive dysfunction and associated pathology in women undergoing military training

Lookup NU author(s): Dr David Woods


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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017.All rights reserved. Introduction Evidence from civilian athletes raises the question of whether reproductive dysfunction may be seen in female soldiers as a result of military training. Such reproductive dysfunction consists of impaired ovulation with or without long-term subfertility. Methods A critical review of pertinent evidence following an extensive literature search. Results The evidence points towards reduced energy availability as the most likely explanation for exerciseinduced reproductive dysfunction. Evidence also suggests that reproductive dysfunction is mediated by activation of the hypothalamic-pituitary-adrenal axis and suppression of the hypothalamic-pituitary-gonadal axis, with elevated ghrelin and reduced leptin likely to play an important role. The observed reproductive dysfunction exists as part of a female athletic triad, together with osteopenia and disordered eating. If this phenomenon was shown to exist with UK military training, this would be of significant concern. We hypothesise that the nature of military training and possibly field exercises may contribute to greater risk of reproductive dysfunction among female military trainees compared with exercising civilian controls. We discuss the features of military training and its participants, such as energy availability, age at recruitment, body phenotype, type of physical training, psychogenic stressors, altered sleep pattern and elemental exposure as contributors to reproductive dysfunction. Conclusions We identify lines of future research to more fully characterise reproductive dysfunction in military women and suggest possible interventions that, if indicated, could improve their future well-being.

Publication metadata

Author(s): Gifford RM, Reynolds RM, Greeves J, Anderson RA, Woods DR

Publication type: Review

Publication status: Published

Journal: Journal of the Royal Army Medical Corps

Year: 2017

Volume: 163

Issue: 5

Pages: 301-310

Online publication date: 05/10/2017

Acceptance date: 27/07/2017

ISSN (print): 0035-8665

Publisher: BMJ Publishing Group


DOI: 10.1136/jramc-2016-000727