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Lookup NU author(s): Dr Cindy LeeORCiD
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A two-step fabrication process combining emulsification-solvent evaporation method for encapsulation of drug in PLGA microparticles followed by supercritical gas foaming was developed to produce drug-releasing biodegradable micro-porous foams. The encapsulation and release of model hydrophobic drug (Curcumin) and of model hydrophilic drug (Gentamicin) were investigated in this work. By utilizing a two-step fabrication process, a uniform dispersion of the drug in PLGA polymer matrix can be achieved and the method can be further adapted for the encapsulation of a wide range of active ingredient (both hydrophobic and hydrophilic) in biodegradable micro-porous scaffold.The in vitro release profile of the drug-encapsulated PLGA foam was studied over a period of 2 weeks and it was observed that the drug release profile can be engineered by the selection of different PLGA polymer blend, varying lactic to glycolic ratio and molecular chain length of the polymer, and by addition of compatible biodegradable polymer such as Polyethylene Glycol (PEG) to the polymer matrix.
Author(s): Ong YXJ, Lee LY, Davoodi P, Wang CH
Publication type: Article
Publication status: Published
Journal: The Journal of Supercritical Fluids
Year: 2018
Volume: 133
Issue: Part 1
Pages: 263-269
Print publication date: 01/03/2018
Online publication date: 20/10/2017
Acceptance date: 20/10/2017
ISSN (print): 0896-8446
Publisher: Elsevier
URL: https://doi.org/10.1016/j.supflu.2017.10.018
DOI: 10.1016/j.supflu.2017.10.018
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