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Hypoxia increases thyroid cancer stem cell-enriched Side population

Lookup NU author(s): Dr Kamilla Mahkamova, Sebastian Aspinall, Dr Annette Meeson

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Hypoxic stress in a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem-cell properties. Hypoxia inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expressed in thyroid cancers. There is growing evidence that the HIF pathway plays a significant role in the maintenance of thyroid cancer stem cells (CSC). We have isolated thyroid CSC from a papillary thyroid cancer derived cell line (BCPAP) and an anaplastic thyroid cancer derived cell line (SW1736) as Side population (SP) cells (a putative stem cell population) and treated them with cobalt chloride (II) to induce hypoxia. We observed an increase in the SP population of cells within the thyroid cancer cell lines following induction of hypoxia.

Publication metadata

Author(s): Mahkamova K, Latar N, Aspinall S, Meeson A

Publication type: Article

Publication status: Published

Journal: World Journal of Surgery

Year: 2018

Volume: 42

Issue: 2

Pages: 350-357

Print publication date: 01/02/2018

Online publication date: 22/11/2017

Acceptance date: 13/10/2017

Date deposited: 10/11/2017

ISSN (print): 0364-2313

ISSN (electronic): 1432-2323

Publisher: Springer

URL: https://doi.org/10.1007/s00268-017-4331-x

DOI: 10.1007/s00268-017-4331-x

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