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A combination of alfaxalone, medetomidine and midazolam for the chemical immobilization of Rhesus macaque (Macaca mulatta): Preliminary results

Lookup NU author(s): Henri Bertrand, Charlotte Sanders, Jennifer Murray, Emeritus Professor Paul FlecknellORCiD


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© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background: Chemical immobilization of non-human primates can be required to perform scientific or veterinary procedure with different invasiveness degrees. This preliminary study was undertaken to assess the clinical effects of a combination of alfaxalone, medetomidine and midazolam (AMM). Methods: Seven rhesus macaques were chemically immobilized, for invasive veterinary procedures, with alfaxan 2 mg kg−1, medetomidine 20 μg kg−1 and midazolam 0.3 mg kg−1 injected subcutaneously. Results: The alfaxalone combination induced surgical anaesthesia, with a complete absence of response to noxious stimuli, for at least 20 minutes. The total duration of anaesthesia was 56 ± 7 minutes, and the administration of atipamezole, to partially reverse the combination effects, did not appear to alter the depth of anaesthesia. Conclusion: In conclusion, the AMM combination produced rapid onset general anaesthesia, following subcutaneous administration of a relatively low volume (0.28 mL/kg) of injectate.

Publication metadata

Author(s): Bertrand HGMJ, Sandersen C, Murray J, Flecknell PA

Publication type: Article

Publication status: Published

Journal: Journal of Medical Primatology

Year: 2017

Volume: 46

Issue: 6

Pages: 332-336

Print publication date: 01/12/2017

Online publication date: 21/09/2017

Acceptance date: 20/08/2017

ISSN (print): 0047-2565

ISSN (electronic): 1600-0684

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/jmp.12315


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