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Lookup NU author(s): Dr Rhona Sinclair, Professor Alexander PhillipsORCiD, Dr Maziar Navidi, Professor Michael Griffin, Dr Christopher Snowden
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© 2017 The Association of Anaesthetists of Great Britain and Ireland Oesophagectomy is a technically-demanding operation associated with a high level of morbidity. We analysed the association of pre-operative variables, including those from cardiopulmonary exercise testing, with complications (logistic regression) and survival and length of stay (Cox regression) after scheduled transthoracic oesophagectomy in 273 adults, in isolation and on multivariate testing (maximum Akaike information criterion). On multivariate analysis, any postoperative complication was associated with ventilatory equivalents for carbon dioxide, odds ratio (95%CI) 1.088 (1.02–1.17), p = 0.018. Cardiorespiratory complications were associated with FEV1 and pre-operative background survival (in an analogous group without cancer), odds ratios (95%CI) 0.55 (0.37–0.80), p = 0.002 and 0.89 (0.82–0.96), p = 0.004, respectively. Survival was associated with the ratio of expected-to-observed ventilatory equivalents for carbon dioxide and predicted postoperative survival, hazard ratios (95%CI) 0.17 (0.03–0.91), p = 0.039 and 0.96 (0.90–1.01), p = 0.076. Length of hospital stay was associated with FVC, hazard ratio (95%CI) 1.38 (1.17–1.63), p < 0.0001.
Author(s): Sinclair RCF, Phillips AW, Navidi M, Griffin SM, Snowden CP
Publication type: Article
Publication status: Published
Journal: Anaesthesia
Year: 2017
Volume: 72
Issue: 12
Pages: 1501-1507
Print publication date: 01/12/2017
Online publication date: 05/10/2017
Acceptance date: 03/09/2017
ISSN (print): 0003-2409
ISSN (electronic): 1365-2044
Publisher: Blackwell Publishing Ltd
URL: https://doi.org/10.1111/anae.14085
DOI: 10.1111/anae.14085
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