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Pre-operative variables including fitness associated with complications after oesophagectomy

Lookup NU author(s): Dr Rhona Sinclair, Professor Alexander PhillipsORCiD, Dr Maziar Navidi, Professor Michael Griffin, Dr Christopher Snowden


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© 2017 The Association of Anaesthetists of Great Britain and Ireland Oesophagectomy is a technically-demanding operation associated with a high level of morbidity. We analysed the association of pre-operative variables, including those from cardiopulmonary exercise testing, with complications (logistic regression) and survival and length of stay (Cox regression) after scheduled transthoracic oesophagectomy in 273 adults, in isolation and on multivariate testing (maximum Akaike information criterion). On multivariate analysis, any postoperative complication was associated with ventilatory equivalents for carbon dioxide, odds ratio (95%CI) 1.088 (1.02–1.17), p = 0.018. Cardiorespiratory complications were associated with FEV1 and pre-operative background survival (in an analogous group without cancer), odds ratios (95%CI) 0.55 (0.37–0.80), p = 0.002 and 0.89 (0.82–0.96), p = 0.004, respectively. Survival was associated with the ratio of expected-to-observed ventilatory equivalents for carbon dioxide and predicted postoperative survival, hazard ratios (95%CI) 0.17 (0.03–0.91), p = 0.039 and 0.96 (0.90–1.01), p = 0.076. Length of hospital stay was associated with FVC, hazard ratio (95%CI) 1.38 (1.17–1.63), p < 0.0001.

Publication metadata

Author(s): Sinclair RCF, Phillips AW, Navidi M, Griffin SM, Snowden CP

Publication type: Article

Publication status: Published

Journal: Anaesthesia

Year: 2017

Volume: 72

Issue: 12

Pages: 1501-1507

Print publication date: 01/12/2017

Online publication date: 05/10/2017

Acceptance date: 03/09/2017

ISSN (print): 0003-2409

ISSN (electronic): 1365-2044

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/anae.14085


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