Lookup NU author(s): Dr Timothy Hardy,
Dr Stuart McPherson
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world. Invasive liver biopsy remains the gold standard method for the diagnosis and staging of NAFLD. The aim of this review is to summarize recent research regarding imaging-based assessment of NAFLD.Novel methods such as controlled attenuation parameter (CAP) and magnetic resonance imaging proton-derived fat fraction (MRI-PDFF) appear promising for steatosis assessment and are currently undergoing validation in NAFLD. Fibrosis can be non-invasively assessed by transient elastography (TE), which is currently the best validated test in NAFLD. MR elastography (MRE) appears very sensitive for fibrosis detection. No imaging technique can accurately detect NASH.TE is inexpensive and relatively widely available and can reliably exclude advanced fibrosis in NAFLD. MRI offers the most promise for steatosis and fibrosis quantification, but further validation of these techniques is needed.
Author(s): Hardy T, McPherson S
Publication type: Review
Publication status: Published
Journal: Current Hepatology Reports
Print publication date: 01/12/2017
Online publication date: 16/11/2017
Acceptance date: 09/10/2016
ISSN (electronic): 2195-9595
Publisher: Springer US