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Pathogenesis and Prognosis of Hepatocellular Carcinoma at the Cellular and Molecular Levels

Lookup NU author(s): Dr Olivier GovaereORCiD

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Abstract

© 2015 Elsevier Inc.Different approaches predict the outcome for patients with hepatocellular carcinoma (HCC). The expression of biliary-hepatic progenitor cell markers generally correlates with poor prognosis. This article focuses on the pathogenesis of HCC, how differentiation or dedifferentiation leads to a phenotype switch, and heterogeneity in the same tumor. A tumor cell decides its fate based on a complex interplay of signaling pathways. Interaction with the microenvironment decides whether it will invade, proliferate, or enter survival mode. Several signaling pathways contribute to stemness features, reflecting a small chemoresistant subpopulation of the tumor that expresses biliary-hepatic progenitor cell markers.

Publication metadata

Author(s): Govaere O, Roskams T

Publication type: Review

Publication status: Published

Journal: Clinics in Liver Disease

Year: 2015

Volume: 19

Issue: 2

Pages: 261-276

Print publication date: 01/05/2015

Online publication date: 03/03/2015

Acceptance date: 01/01/1900

ISSN (print): 1089-3261

ISSN (electronic): 1557-8224

Publisher: W.B. Saunders

URL: https://doi.org/10.1016/j.cld.2015.01.002

DOI: 10.1016/j.cld.2015.01.002

PubMed id: 25921662

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