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Lookup NU author(s): Professor Colin Harwood
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Genome annotation is, nowadays, performed via automatic pipelines that cannot discriminate between right or wrong annotations. Given their important in increasing the accuracy of the genome annotations of other organisms, it is critical that the annotations of model organisms reflect the current annotation gold standard. The genome of Bacillus subtilis strain 168 was sequenced twenty years ago. Using a combination of inductive, deductive and abductive reasoning, we present a unique, manually curated annotation, essentially based on experimental data. This reveals how this bacterium lives in a plant niche, while carrying a paleome operating system common to Firmicutes and Tenericutes. Dozens of new genomic objects and an extensive literature survey have been included for the sequence available at the INSDC (AccNum AL009126.3). We also propose an extension to Demerec’s nomenclature rules that will help investigators connect to this type of curated annotation via the use of common gene names.
Author(s): Borriss R, Danchin A, Harwood CR, Médigue C, Rocha EPC, Sekowska A, Vallenet D
Publication type: Article
Publication status: Published
Journal: Microbial Biotechnology
Print publication date: 01/01/2018
Online publication date: 26/12/2017
Acceptance date: 05/12/2017
Date deposited: 01/01/2018
ISSN (electronic): 1751-7915
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