Browse by author
Lookup NU author(s): Professor Moein MoghimiORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2017 Elsevier Ltd. Injection/infusion reactions to nanopharmaceuticals (and particulate drug carriers) are idiosyncratic and well documented. The molecular basis of nanoparticle-mediated injection reactions is debatable, with two hypotheses as front-runners. The first is complement-activation-related 'pseudoallergy', where a causal role for nanoparticle-mediated complement activation in injection/infusion reactions is considered. However, the second hypothesis (the rapid phagocytic response hypothesis) states a transitional link from robust clearance of nanoparticles (NPs) from the blood by strategically placed responsive macrophages to adverse hemodynamic and cardiopulmonary reactions, regardless of complement activation. Here, I critically examine and discuss these hypotheses. Current experimentally derived evidence appears to be more in support of the rapid phagocytic response hypothesis than of the pseudoallergy hypothesis.
Author(s): Moghimi SM
Publication type: Article
Publication status: Published
Journal: Drug Discovery Today
Year: 2018
Volume: 23
Issue: 5
Pages: 1034-1042
Print publication date: 01/05/2018
Online publication date: 13/11/2017
Acceptance date: 02/04/2016
ISSN (print): 1359-6446
ISSN (electronic): 1878-5832
Publisher: Elsevier Ltd
URL: https://doi.org/10.1016/j.drudis.2017.11.006
DOI: 10.1016/j.drudis.2017.11.006
Altmetrics provided by Altmetric