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Investigating the generalisation of an atlas-based synthetic-CT algorithm to another centre and MR scanner for prostate MR-only radiotherapy

Lookup NU author(s): JJ Wyatt, Dr Charles Kelly, Dr Hazel McCallum


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© 2017 Institute of Physics and Engineering in Medicine. There is increasing interest in MR-only radiotherapy planning since it provides superb soft-tissue contrast without the registration uncertainties inherent in a CT-MR registration. However, MR images cannot readily provide the electron density information necessary for radiotherapy dose calculation. An algorithm which generates synthetic CTs for dose calculations from MR images of the prostate using an atlas of 3 T MR images has been previously reported by two of the authors. This paper aimed to evaluate this algorithm using MR data acquired at a different field strength and a different centre to the algorithm atlas. Twenty-one prostate patients received planning 1.5 T MR and CT scans with routine immobilisation devices on a flat-top couch set-up using external lasers. The MR receive coils were supported by a coil bridge. Synthetic CTs were generated from the planning MR images with (sCT1V) and without (sCT) a one voxel body contour expansion included in the algorithm. This was to test whether this expansion was required for 1.5 T images. Both synthetic CTs were rigidly registered to the planning CT (pCT). A 6 MV volumetric modulated arc therapy plan was created on the pCT and recalculated on the sCT and sCT1V. The synthetic CTs' dose distributions were compared to the dose distribution calculated on the pCT.

Publication metadata

Author(s): Wyatt JJ, Dowling JA, Kelly CG, McKenna J, Johnstone E, Speight R, Henry A, Greer PB, McCallum HM

Publication type: Article

Publication status: Published

Journal: Physics in Medicine and Biology

Year: 2017

Volume: 62

Issue: 24

Pages: N548-N560

Online publication date: 21/11/2017

Acceptance date: 27/10/2017

ISSN (print): 0031-9155

ISSN (electronic): 1361-6560

Publisher: Institute of Physics Publishing


DOI: 10.1088/1361-6560/aa9676


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