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Decreased male reproductive success in association with mitochondrial dysfunction

Lookup NU author(s): Dr Mika Martikainen, Dr John Grady, Dr Yi NgORCiD, Dr Charlotte Alston, Professor Grainne Gorman, Professor Robert Taylor, Professor Bobby McFarlandORCiD, Emeritus Professor Doug Turnbull

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Abstract

The reproductive success of men with mitochondrial disease is to date unreported. We compared the age- and era-adjusted reproductive success of 94 British male patients with mitochondrial disease to that of the UK general male population. The reproductive success of men with mitochondrial disease was 65% of that in the general population (95% confidence interval: 53%; 79%), and the effect magnitude was related to the disease severity. This contrasts with the two previous studies finding that the reproductive success of women with mitochondrial DNA disease is not impaired. We conclude that the reproductive health of men with mitochondrial disease merits increased clinical attention.

Publication metadata

Author(s): Martikainen MH, Grady JP, Ng YS, Alston CL, Gorman GS, Taylor RW, McFarland R, Turnbull DM

Publication type: Article

Publication status: Published

Journal: European Journal of Human Genetics

Year: 2017

Volume: 25

Issue: 10

Pages: 1162-1164

Online publication date: 16/08/2017

Acceptance date: 20/06/2017

ISSN (print): 1018-4813

ISSN (electronic): 1476-5438

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/ejhg.2017.114

DOI: 10.1038/ejhg.2017.114

PubMed id: 28812649

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