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Corticospinal gating during action preparation and movement in the primate motor cortex

Lookup NU author(s): Dr Demetris Soteropoulos

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

During everyday actions there is a need to be able to withhold movements until the most appropriate time. This motor inhibition is likely to rely on multiple cortical and subcortical areas, but the primary motor cortex (M1) is a critical component of this process. However, the mechanisms behind this inhibition are unclear, and in particular the role of the corticospinal system, which is most often associated with driving muscles and movement. In order to address this, recordings were made from identified corticospinal (PTNs, n=94) and corticomotoneuronal (CM, n=16) cells from the primary motor cortex during an instructed delay reach to grasp task. The task involved the animals withholding action for ~2s until a GO cue, after which they were allowed to reach and perform the task for a food reward. Analysis of the firing of cells in M1 during the delay period revealed that as a population, non-CM PTNs showed significant suppression in their activity during the cue and instructed delay periods, while CM cells instead showed a facilitation during the preparatory delay. Analysis of cell activity during movement also revealed that a substantial minority of PTNs (27%) showed suppressed activity during movement, a response pattern more suited to cells involved in withholding rather than driving movement. These results demonstrate the potential contributions of the M1 corticospinal system to withholding of actions and highlight that suppression of activity in M1 during movement preparation is not evenly distributed across different neural populations.


Publication metadata

Author(s): Soteropoulos DS

Publication type: Article

Publication status: Published

Journal: Journal of Neurophysiology

Year: 2018

Volume: 119

Issue: 4

Pages: 1538-1555

Print publication date: 01/04/2018

Online publication date: 18/04/2018

Acceptance date: 01/01/2018

Date deposited: 26/02/2018

ISSN (print): 0022-3077

ISSN (electronic): 1522-1598

Publisher: American Physiological Society

URL: https://doi.org/10.1152/jn.00639.2017

DOI: 10.1152/jn.00639.2017

PubMed id: 29357454


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