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Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention

Lookup NU author(s): Professor Quentin AnsteeORCiD, Dr Timothy Hardy

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Abstract

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. NAFLD is one of the most important causes of liver disease worldwide and will probably emerge as the leading cause of end-stage liver disease in the coming decades, with the disease affecting both adults and children. The epidemiology and demographic characteristics of NAFLD vary worldwide, usually parallel to the prevalence of obesity, but a substantial proportion of patients are lean. The large number of patients with NAFLD with potential for progressive liver disease creates challenges for screening, as the diagnosis of NASH necessitates invasive liver biopsy. Furthermore, individuals with NAFLD have a high frequency of metabolic comorbidities and could place a growing strain on health-care systems from their need for management. While awaiting the development effective therapies, this disease warrants the attention of primary care physicians, specialists and health policy makers.

Publication metadata

Author(s): Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E

Publication type: Review

Publication status: Published

Journal: Nature Reviews Gastroenterology and Hepatology

Year: 2018

Volume: 15

Issue: 1

Pages: 11-20

Print publication date: 01/01/2018

Online publication date: 20/09/2017

Acceptance date: 02/04/2016

ISSN (print): 1759-5045

ISSN (electronic): 1759-5053

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/nrgastro.2017.109

DOI: 10.1038/nrgastro.2017.109

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