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Lookup NU author(s): Emeritus Professor Philip Home
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2017. Aim: To describe in type 2 diabetes the 24-hour distribution of hypoglycaemia and compare the frequency of nocturnal events based on a predefined nocturnal window or an expanded interval, using illustrative data for two insulin glargine formulations. Methods: Temporal distribution of hypoglycaemic events was assessed descriptively and by profile using participant-level data from three randomized trials comparing insulin glargine 300 U/mL (Gla-300) and 100 U/mL (Gla-100). Risk of hypoglycaemia and annualized event rates were compared for the predefined nocturnal interval (00:00 to 05:59. h) and an expanded window (22:00. h to the pre-breakfast glucose measurement). Results: Confirmed (≤. 3.9. mmol/L [≤. 70 mg/dL]) or severe hypoglycaemic events were reported most frequently between 06:00 and 10:00 h with both insulins. Nearly threefold more events were identified using the expanded nocturnal interval. Risk of ≥. 1 nocturnal event was 25% lower with Gla-300 than Gla-100 with the predefined, and 16% lower with the expanded interval; annualized event rates were 31% and 24% lower with the predefined and expanded window, respectively. The between-insulin difference in number of nocturnal events depended markedly on the chosen nocturnal interval (556 vs. 1145 fewer events with Gla-300 using the predefined vs. expanded interval). Conclusions: The predefined 00:00-05:59. h nocturnal interval excluded many hypoglycaemic events occurring during the actual overnight interval. While Gla-300 reduced hypoglycaemic events versus Gla-100 (regardless of the interval considered), the results obtained using the expanded window better reflect the clinical experience of people treated with basal insulin.
Author(s): Riddle MC, Bolli GB, Avogaro A, Alvarez MG, Merino-Trigo A, Boelle-Le Corfec E, Home PD
Publication type: Article
Publication status: Published
Journal: Diabetes and Metabolism
Print publication date: 01/09/2018
Online publication date: 11/12/2017
Acceptance date: 03/12/2017
Date deposited: 17/01/2018
ISSN (print): 1262-3636
ISSN (electronic): 1878-1780
Publisher: Elsevier Masson SAS
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