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Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention: Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry

Lookup NU author(s): Professor Azfar Zaman



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2017 American College of Cardiology Foundation Objectives High platelet reactivity (HPR) was studied in patients presenting with ST-segment elevation myocardial infarction (STEMI) due to stent thrombosis (ST) undergoing immediate percutaneous coronary intervention (PCI). Background HPR on P2Y12 inhibitors (HPR-ADP) is frequently observed in stable patients who have experienced ST. The HPR rates in patients presenting with ST for immediate PCI are unknown. Methods Consecutive patients presenting with definite ST were included in a multicenter ST registry. Platelet reactivity was measured before immediate PCI with the VerifyNow P2Y12 or Aspirin assay. Results Platelet reactivity was measured in 129 ST patients presenting with STEMI undergoing immediate PCI. HPR-ADP was observed in 76% of the patients, and HPR on aspirin (HPR-AA) was observed in 13% of the patients. HPR rates were similar in patients who were on maintenance P2Y12 inhibitor or aspirin since stent placement versus those without these medications. In addition, HPR-ADP was similar in patients loaded with a P2Y12 inhibitor shortly before immediate PCI versus those who were not. In contrast, HPR-AA trended to be lower in patients loaded with aspirin as compared with those not loaded. Conclusions Approximately 3 out of 4 ST patients with STEMI undergoing immediate PCI had HPR-ADP, and 13% had HPR-AA. Whether patients were on maintenance antiplatelet therapy while developing ST or loaded with P2Y12 inhibitors shortly before undergoing immediate PCI had no influence on the HPR rates. This raises concerns that the majority of patients with ST have suboptimal platelet inhibition undergoing immediate PCI.

Publication metadata

Author(s): Godschalk TC, Byrne RA, Adriaenssens T, Malik N, Feldman LJ, Guagliumi G, Alfonso F, Neumann F-J, Trenk D, Joner M, Schulz C, Steg PG, Goodall AH, Wojdyla R, Dudek D, Wykrzykowska JJ, Hlinomaz O, Zaman AG, Curzen N, Dens J, Sinnaeve P, Desmet W, Gershlick AH, Kastrati A, Massberg S, ten Berg JM

Publication type: Article

Publication status: Published

Journal: JACC: Cardiovascular Interventions

Year: 2017

Volume: 10

Issue: 24

Pages: 2548-2556

Print publication date: 26/12/2017

Online publication date: 18/12/2017

Acceptance date: 18/09/2017

Date deposited: 13/03/2018

ISSN (print): 1936-8798

ISSN (electronic): 1876-7605

Publisher: Elsevier Inc.


DOI: 10.1016/j.jcin.2017.09.019


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