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β2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function

Lookup NU author(s): Leonie Schittenhelm, Professor Catharien Hilkens



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Emerging evidence suggests that the β2 integrin family of adhesion molecules have an important role in suppressing immune activation and in ammation. β2 integrins are important adhesion and signaling molecules that are exclusively expressed on leuko- cytes. The four β2 integrins (CD11a, CD11b, CD11c, and CD11d paired with the β2 chain CD18) play important roles in regulating three key aspects of immune cell function: recruitment to sites of in ammation; cell–cell contact formation; and downstream effects on cellular signaling. Through these three processes, β2 integrins both contribute to and regulate immune responses. This review explores the pro- and anti-in ammatory effects of β2 integrins in monocytes, macrophages, and dendritic cells and how they in uence the outcome of immune responses. We furthermore discuss how imbalances in β2 integrin function can have far-reaching effects on mounting appropriate immune responses, potentially in uencing the development and progression of autoimmune and in ammatory diseases. Therapeutic targeting of β2 integrins, therefore, holds enormous potential in exploring treatment options for a variety of in ammatory conditions.

Publication metadata

Author(s): Schittenhelm L, Hilkens CM, Morrison VL

Publication type: Review

Publication status: Published

Journal: Frontiers in Immunology

Year: 2017

Volume: 8

Print publication date: 20/12/2017

Online publication date: 20/12/2017

Acceptance date: 08/12/2017

ISSN (electronic): 1664-3224


DOI: 10.3389/fimmu.2017.01866

PubMed id: 29326724