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Asenjonamides A–C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Lookup NU author(s): Professor Alan Bull, Professor Michael Goodfellow


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© 2018 Japan Antibiotics Research Association Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A–C (1–3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A–E (5–9), and seven known diketopiperazines (10–16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

Publication metadata

Author(s): Abdelkader MSA, Philippon T, Asenjo JA, Bull AT, Goodfellow M, Ebel R, Jaspars M, Rateb ME

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2018

Volume: 71

Issue: 4

Pages: 425-431

Print publication date: 01/04/2018

Online publication date: 23/01/2018

Acceptance date: 02/11/2017

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group


DOI: 10.1038/s41429-017-0012-0


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