Toggle Main Menu Toggle Search

Open Access padlockePrints

Bacterial outer membrane constriction

Lookup NU author(s): Dr Alexander Egan


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2018 John Wiley & Sons Ltd. The outer membrane of Gram-negative bacteria is a crucial permeability barrier allowing the cells to survive a myriad of toxic compounds, including many antibiotics. This innate form of antibiotic resistance is compounded by the evolution of more active mechanisms of resistance such as efflux pumps, reducing the already limited number of clinically relevant treatments for Gram-negative pathogens. During cell division Gram-negative bacteria must coordinate constriction of the outer membrane in conjunction with other crucial layers of the cell envelope, the peptidoglycan cell wall and the inner membrane. Coordination is crucial in maintaining structural integrity of the envelope, and represents a highly vulnerable time for the cell as any failure can be fatal, if not least disadvantageous. However, the molecular mechanisms of cell division and how the biogenesis of the three layers is synchronised during constriction remain largely unknown. Perturbations of the outer membrane have been shown to increase the effectiveness of antibiotics in vitro, and so with improved understanding of this process we may be able to exploit this vulnerability and improve the effectiveness of antibiotic treatments. In this review the current knowledge of how Gram-negative bacteria facilitate constriction of their outer membranes during cell division will be discussed.

Publication metadata

Author(s): Egan AJF

Publication type: Article

Publication status: Published

Journal: Molecular Microbiology

Year: 2018

Volume: 107

Issue: 6

Pages: 676-687

Print publication date: 01/03/2018

Online publication date: 08/01/2018

Acceptance date: 03/01/2018

ISSN (print): 0950-382X

ISSN (electronic): 1365-2958

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/mmi.13908


Altmetrics provided by Altmetric