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The delirium and population health informatics cohort study protocol: ascertaining the determinants and outcomes from delirium in a whole population

Lookup NU author(s): Dr Sarah Richardson



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Background: Delirium affects 25% of older inpatients and is associated with long-term cognitive impairment andfuture dementia. However, no population studies have systematically ascertained cognitive function before, cognitivedeficits during, and cognitive impairment after delirium. Therefore, there is a need to address the following question:does delirium, and its features (including severity, duration, and presumed aetiologies), predict long-term cognitiveimpairment, independent of cognitive impairment at baseline?Methods: The Delirium and Population Health Informatics Cohort (DELPHIC) study is an observational populationbasedcohort study based in the London Borough of Camden. It is recruiting 2000 individuals aged ≥70 years andprospectively following them for two years, including daily ascertainment of all inpatient episodes for delirium. Dailyinpatient assessments include the Memorial Delirium Assessment Scale, the Observational Scale for Level of Arousal,and the Hierarchical Assessment of Balance and Mobility. Data on delirium aetiology is also collected. The primaryoutcome is the change in the modified Telephone Interview for Cognitive Status at two years.Discussion: DELPHIC is the first population sample to assess older persons before, during and after hospitalisation. Thecumulative incidence of delirium in the general population aged ≥70 will be described. DELPHIC offers the opportunityto quantify the impact of delirium on cognitive and functional outcomes. Overall, DELPHIC will provide a real-timepublic health observatory whereby information from primary, secondary, intermediate and social care can beintegrated to understand how acute illness is linked to health and social care outcomes.

Publication metadata

Author(s): Davis D, Richardson SJ, Hornby J, Bowden H, Hoffmann K, Weston-Clarke M, Green F, Chaturvedi N, Hughes A, Kuh D, Sampson E, Mizoguchi R, Cheah KL, Romain M, Sinha A, Jenkin R, Brayne C, MacLullich A

Publication type: Article

Publication status: Published

Journal: BMC Geriatrics

Year: 2018

Volume: 18

Online publication date: 09/02/2018

Acceptance date: 05/02/2018

Date deposited: 15/02/2018

ISSN (electronic): 1471-2318

Publisher: BioMed Central


DOI: 10.1186/s12877-018-0742-2


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