Small-Molecule Probes of Plant Glycopolymer Metabolism

Rugen, MD; Andriotis, VME; Field, RA

doi:10.1016/B978-0-12-409547-2.12657-5

Small-Molecule Probes of Plant Glycopolymer Metabolism

Lookup NU author(s): Dr Vasilios Andriotis ORCiD

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Abstract

Small-molecule probes can be used in conjunction with traditional genetic and biochemical methods to gain a better understanding of metabolic processes. Chemical genetics has been significantly utilized in the areas of plant hormones and herbicide development; chemical probes have become established tools for the dissection of signaling pathways and for agrochemical applications. Herein we discuss the use of small-molecule probes in the field of plant carbohydrate research, with particular focus on noncovalent probes. The use of direct inhibitors such as iminosugars, metabolic incorporation of labels, and indirect inhibition of carbohydrate processing have helped provide insight into key areas of plant carbohydrate metabolism, including starch, cell wall, glycoprotein and glycolipid synthesis, degradation, and spatial organization.