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The hidden lipoproteome of Staphylococcus aureus

Lookup NU author(s): Professor Rick Lewis

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Abstract

© 2018 Elsevier GmbH. Lipoproteins are attached to the outer leaflet of the membrane by a di- or tri-acylglyceryl moiety and are thus positioned in the membrane-cell wall interface. Consequently, lipoproteins are involved in many surface associated functions, including cell wall synthesis, electron transport, uptake of nutrients, surface stress response, signal transduction, and they represent a reservoir of bacterial virulence factors. Inspection of 123 annotated Staphylococcus aureus genome sequences in the public domain revealed that this organism devotes about 2-3% of its coding capacity to lipoproteins, corresponding to about 70 lipoproteins per genome. 60 of these lipoproteins were identified in 95% of the genomes analyzed, which thus constitute the core lipoproteome of S. aureus. 30% of the conserved staphylococcal lipoproteins are substrate-binding proteins of ABC transporters with roles in nutrient transport. With a few exceptions, much less is known about the function of the remaining lipoproteins, representing a large gap in our knowledge of this functionally important group of proteins. Here, we summarize current knowledge, and integrate information from genetic context analysis, expression and regulatory data, domain architecture, sequence and structural information, and phylogenetic distribution to provide potential starting points for experimental evaluation of the biological function of the poorly or uncharacterized lipoproteome of S. aureus.

Publication metadata

Author(s): Graf A, Lewis RJ, Fuchs S, Pagels M, Engelmann S, Riedel K, Pane-Farre J

Publication type: Article

Publication status: Published

Journal: International Journal of Medical Microbiology

Year: 2018

Volume: 308

Issue: 6

Pages: 569-581

Print publication date: 01/08/2018

Online publication date: 01/02/2018

Acceptance date: 27/01/2018

ISSN (print): 1438-4221

ISSN (electronic): 1618-0607

Publisher: Elsevier GmbH - Urban und Fischer

URL: https://doi.org/10.1016/j.ijmm.2018.01.008

DOI: 10.1016/j.ijmm.2018.01.008

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