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Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection

Lookup NU author(s): Sebastian Mafeld, Jeremy French, Dr Dina Tiniakos, Dr Beate Haugk, Professor Derek Manas, Dr Peter Littler



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


We describe a 52-year-old female patient who presented with a 9.5-cm fibrolamellar hepatocellular carcinoma (FL-HCC). The patient was initially unsuitable for surgical resection and therefore underwent transarterial chemoembolization followed by selective internal radiation therapy (SIRT) with Yttrium-90 to downsize the tumour. Following SIRT, the tumour decreased in volume from 350 to 20 cm3 allowing curative (R0) resection with an extended left hepatectomy and reconstruction of IVC. This is the first reported case of FL-HCC treated with SIRT in which, due to the good SIRT response, the patient was downsized to allow curative resection.

Publication metadata

Author(s): Mafeld S, French J, Tiniakos D, Haugk B, Manas D, Littler P

Publication type: Article

Publication status: Published

Journal: CardioVascular and Interventional Radiology

Year: 2018

Volume: 41

Issue: 5

Pages: 816-820

Print publication date: 01/05/2018

Online publication date: 21/02/2018

Acceptance date: 10/02/2018

Date deposited: 27/02/2018

ISSN (print): 0174-1551

ISSN (electronic): 1432-086X

Publisher: Springer New York LLC


DOI: 10.1007/s00270-018-1903-6


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